Bioorganic Chemistry Research Group
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Welcome to the Bioorganic Chemistry Research Group

The Bioorganic Chemistry group focus its activity on pursuing new insights in to our understanding of health related biological processes. With a wide experience on asymmetric organic synthesis the group is interested in the design and synthesis of small molecules for therapeutic application or their use in the elucidation of biological function. By combining a series of multidisciplin ary tools and techniques including in-house developed synthetic methodologies, computer-based molecular modelling (QM calculations, docking and Molecular Dynamics) and advanced spectroscopic techniques (i.e. STD-NMR), the main activity of the group concerns identification of small molecules as key modulators and/or inhibitors of target enzymes associated to specific biological functions. This approach provides target validation as well as starting points for further drug discovery.
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Pre-Doctoral Grant available.  
Ph.D. Thesis:
Diseño y síntesis de inhibidores de transglicosilasas fúngicas
May 29, 2017
Fernando Gomollon
Ph.D. Thesis:
New glycomimetic ligands targeting human glycosyltransferases
May 3, 2017
Mattia Ghirardello
Inside Cover
in Org. Biomol. Chem.
Review on Reactivity
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Cover Picture (Hot paper)
in Chem. Eur. J.
Congratulations Vero!
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Cover Picture (Editor`s choice) in
Chem. Biol. Drug Design
Congratulations Eduardo!
Posted February 10, 2017  
Our group has been awarded with a FPI pre-doctoral grant for carrying out Ph.D. studies in our laboratories on synthesis of inhibitors (glycomimetics) targeting glycosyltransferasas. The call will be published in the next call of FPI grants. If you are interested in joining us write to e-mail indicated under "Contact" or contact directly Prof. Pedro Merino or Prof. Tomas Tejero.  
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A New Perspective to Study Organic Reactivity  
Posted April 2, 2017  
The reactivity of nitrones in cycloadditions and related reactions is revisited by introducing a topological perspective.

 
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Organocatalytic Oxa-Michael Reactions  
Posted March 3, 2017  
A collaboration with Prof. Vicario's research group at the University of Basque Country (Bilbao, Spain) showed that 2-hydroxydihydropyran-5-ones behave as excellent polyfunctional reagents able to react with enals through oxa-Michael/Michael process cascade under the combination of iminium and enamine catalysis.
 
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Inhibitors of Isoprenoid Biosynthesis  
Posted February 10, 2017  
A review. approaches currently employed to synthesize new inhibitors of isoprenoid biosynthesis.

 
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Highly Enantioselective Organocatalytic Reactions with Nitrone Ylides.  
Posted February 10, 2017  
A new publication from Vero's Ph.D. Thesis. Congratulations Vero!. The work made in collaboration with Prof. Vicario's research group at the University of Basque Country (Bilbao, Spain) established that reaction of nitrones with enals under iminium activation can be modulated by using cooperative H-bonding catalysis to induce the participation of a nitrone ylide (C-N-C) instead of the classical C-N-O dipole
 
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Evidences of Carbocation Intermediates in Thionation of Alcohols  
Posted February 10, 2017  
Evidences that carbocations are involved in the mechanism of the thionation of alcohols with Lawesson's reagent have been found. The mechanism is completely different to that recently established for thionation of carbonyls. The presence of a phenyl ring at the alcoholic carbon exerts a pivotal role in the stability of the carbocation, enabling an S-π interaction which is crucial for favoring thionation instead undesired elimination. The study is in a complete agreement with the different behavior observed experimentally for primary, secondary and tertiary alcohols (bearing a phenyl ring or not) and predict the best conditions for minimizing undesired elimination.
 
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